The most significant consequence of oxidative stress in the body is thought to be damage to DNA.
DNA may be modified in a variety of ways, which can ultimately lead to mutations and genomic instability.
This could result in the development of a variety of cancers including colon, breast, and prostate.
What happens when DNA is damaged?
DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of standard base pairs. DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly.
Can damaged DNA repair itself?
Fortunately, your cells have repair mechanisms to detect and correct many types of DNA damage. Repair processes that help fix damaged DNA include: Direct reversal: Some DNA-damaging chemical reactions can be directly “undone” by enzymes in the cell.
What are the types of DNA damage?
Spontaneous damage to DNA. There are two major forms of spontaneous DNA damage: (A) deamination of adenine, cytosine, and guanine, and (B) depurination (loss of purine bases) resulting from cleavage of the bond between the purine bases and deoxyribose, (more)
How does damaged DNA cause cancer?
DNA Damage, Mutagenesis and Cancer. Damaged DNA replication may lead to gene mutations, which in turn may give rise to altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle can generate a clonal cell population with a distinct advantage in proliferation.